Synthetic Biology

Hello everybody,

I hope you would be astonished if i talk about a world where you assemble biologicals parts to make a novel system through mathetical modelling !!!!!!!!!!!!!!!!!!

The recent article in 'Nature' states that.....

'Engineering artificial gene networks from modular components is a major goal of synthetic biology. However, the construction of gene networks with predictable functions remains hampered by a lack of suitable components and the fact that assembled networks often require extensive, iterative retrofitting to work as intended. Here we present an approach that couples libraries of diversified components (synthesized with randomized nonessential sequence) with in silico modeling to guide predictable gene network construction without the need for post hoc tweaking. We demonstrate our approach in Saccharomyces cerevisiae by synthesizing regulatory promoter libraries and using them to construct feed-forward loop networks with different predicted input-output characteristics. We then expand our method to produce a synthetic gene network acting as a predictable timer, modifiable by component choice. We use this network to control the timing of yeast sedimentation, illustrating how the plug-and-play nature of our design can be readily applied to biotechnology. '

Yeap I am working on the synthetic biology to understand the translational mechanism in the Yeast. the project is expected to adopt the novel approach of using translational control mechanism to control gene expression in the budding yeast.